Second Son takes place in 2016, seven years after Infamous 2's Conduit protagonist Cole MacGrath sacrifices himself to cure humanity of a mysterious plague. Cole uses the powerful Ray Field Inhibitor weapon, which kills him and most of the other Conduits. The United States government establishes the D.U.P. to hunt down and capture the world's remaining Conduits, dubbing Conduits with the pejorative "Bio-Terrorists". The protagonist is Delsin Rowe, a graffiti artist and the local delinquent of the Akomish reservation. Delsin has the unique Conduit ability of Power Absorption, allowing him to use other Conduits' powers. His brother, Reggie (Travis Willingham), is the local sheriff, and often arrests Delsin for his acts of vandalism. Both are Akomish Native Americans, whose territory lies at the shore of Salmon Bay, Washington. The antagonist is Brooke Augustine, the director of the D.U.P. and a Conduit with power over Concrete. Her actions in the Akomish reservation drive Delsin to travel to Seattle, now under lockdown by D.U.P. forces. Delsin and Reggie encounter three other Conduits: Henry "Hank" Daughtry, a convict with control over Smoke; Abigail "Fetch" Walker, an ex-junkie who uses her Neon powers to hunt down the illegal drug dealers in Seattle; and Eugene Sims, a reclusive video gamer who uses his Video powers to save suspected Conduits from the D.U.P.