I ran Yunohost for nearly a year. The number of times I had to get a shell open and fix something was too many. Yunohost is basically a set of scripts to configure a Debian machine, so if you don't mind fiddling it's probably fine. Cloudron is containerized and basically handles all the 'glue' for you. I've never had to manually fiddle with anything, although it provides the means to.

CC: @killyourfm @thedoctor