Followed the adventures of Mike Malone and Jerry Austin as they drove trucks across the US and Canada for the fictitious C&A Transport Company Ltd. "Cannonball" was a half-hour family drama featuring truckers Mike Malone and Jerry Austin hauling freight across Canada and the U.S.A. Paul Birch and William Campbell portrayed the main characters, with Canadian actors Beth Lockerbie, Beth Morris, Steve Barringer, Howard Milsom, and others in supporting roles.

A framed Texas rancher escapes from prison for a showdown with a saloonkeeper.

After a wild night, wealthy Michael Reston's adulterous wife Charleen comes home with her dress in rags; murder results. Top New York defense lawyer J.G. Blane, whose own marriage exists in name only, arrives in Desert View, Nevada to find the townsfolk and politically powerful Sheriff Hoak distinctly hostile to the Restons. In due course, Blane discovers he's been "taken for a ride," and that quiet desert communities can be deadly.

An aborted mission strands a crew on Venus where they find the planet inhabited only by women led by their evil Queen Yllana. Yllana had all the men of Venus killed, now that's she met Earth men, she wants them dead, too.

An alien from planet Davanna, whose population has developed a terminal blood disease caused by nuclear radiation, is sent to Earth to acquire fresh human blood for his people.