A man suffering from debilitating migraines uses trepanation to cure his condition and realize his mind’s full potential, and discovers the dark side of the ancient surgical practice. By drilling a hole into his skull, Tristan will not only realize the true potential of his mind, but also gain access to a clandestine home for runaways known as the Garden. But just when it begins to look like Tristan is on the path to enlightenment, he’s plunged into a terrifying world of eternal darkness.

In 1957, insurance investigator George Lazarus is tasked with interviewing twelve employees of the Deadly Sin Cigarette Company when his firm receives a suspicious insurance claim. He learns that all twelve had been let go after contracting mysterious illnesses, but before he can report back, Lazarus goes missing without a trace. After his disappearance, his fiancée Bethany and his friend Chip set out to find him - but what they uncover may actually signal the end of the entire human race.

A disillusioned woman tries to gain control of her life as the people closest to her begin to die mysteriously.