Feeling lonely and neglected by her overworked husband, Roxy, a Depression-era farm wife, is drawn into an ill-advised affair with Jack, their hired hand.

When fellow operatives (and childhood friends) Matthew Johnson and Melvin Johnson disappear during an undercover mission in Hong Kong, Cleopatra Jones (Tamara Dobson) travels there to find them. With the help of local detective Mi Ling, Cleopatra discovers that her friends' disappearance has to do with The Dragon Lady, a much-feared blonde "lipstick lesbian" who runs a Macao casino and controls a major chunk of the local drug trade