End of Innocence is a two-part television film that focuses on the work of the German Uranium Association during World War II.

At Farm Hall in England, the ten German nuclear scientists interned there as part of Operation Epsilon learn of the dropping of the first atomic bomb on Hiroshima in August 1945. In flashbacks, the development of the German uranium project is recapitulated chronologically from the discovery of nuclear fission by Otto Hahn to the work of Kurt Diebner at the Heereswaffenamt to the experiments of the Kaiser Wilhelm Institute for Physics under Werner Heisenberg and Carl Friedrich von Weizsäcker at the Haigerloch research reactor in spring 1945.

Forensic biologist Inga Ehrenberg is so absorbed in her work at the Forensic Medicine Institute that she doesn't initially notice how lonely she is after her divorce a few years ago. It is only when her father claims that she has a half-sister and a falconer asks her to take care of a young falcon that she finds herself in a whirlwind of long-hidden, painful feelings. She begins to tame the falcon, convinced that the bird will never leave her.