A shot breaks the silence of the night, four men flee from the scene of the crime. Umberto "Yes and No", the infallible killer of the Caputo clan, has just killed the wrong man. Now he will have to account to the boss. Unfortunately, the victim is the nephew of Tonino O 'Infame, the city's most feared boss. But this does not seem to be the biggest problem: Umberto "Yes and No" hides a terrible secret.

Andrea (Riccardo Maria Manera) is a young man who lives with the surprises and hardships of life. He lives with his best friend, seeks to complete his studies and has an ex-girlfriend who plays with him like cat and mouse. When he discovers that he has an incurable disease, the world collapses on him. Can an illness change a person's life... for the better? Thanks to Giulia (Jenny De Nucci), Andrea will understand that the time has come to assume what remains of her own existence.