Agent Jack Ryan becomes acting Deputy Director of Intelligence for the CIA when Admiral Greer is diagnosed with cancer. When an American businessman, and friend of the president, is murdered on his yacht, Ryan starts discovering links between the man and drug dealers. As former CIA agent John Clark is sent to Colombia to kill drug cartel kingpins in retaliation, Ryan must fight through multiple cover-ups to figure out what happened and who's responsible.

Five-thousand-year-old vampire Miriam promises her lovers the gift of eternal life. When John, her cellist companion for centuries, discovers that he has suddenly begun growing old, he attempts to seek out the help of Dr. Sarah Roberts, a researcher on the mechanisms of aging.