Five independent, career-driven women living in the Ode to Joy apartment building navigate love, ambition, and personal growth as they chase fulfillment on their own terms. As they try to make it in the big city, each faces unique challenges and romantic entanglements while discovering who they truly want to be.

根据豆瓣阅读李大发同名小说改编。 警察耿耕遇到一起妻子报案说丈夫杀害“小三”的案件，报案人正是五年前一桩绑架悬案的受害者母亲马红蕾。马红蕾的丈夫杨英明是设计院的小领导，一家人经常帮扶发小陈晓莲和赵顺奎夫妇，两家的女儿杨文竹和赵小满也处成了好朋友。赵小满因一起爆炸事故严重烧伤毁容，高考结束后，杨文竹和黎露、林皓两个同学一起去看望她，却意外遭绑架。林皓身亡，两个女孩下落不明，耿耕因侦破不力等被停职。由此，马红蕾开始了漫漫五年寻女路，夫妻俩因为聚少离多渐渐离心，同为母亲的陈晓莲却坚定地陪伴着马红蕾，两家人的交往没有因为杨文竹的失踪疏远。随着杀人案的真相浮出水面，这起五年前的旧案也有了新的线索……