In a research lab, a scientist's pet chimpanzee mixes up an invisibility formula. A young woman accidentally drinks the solution and becomes invisible.

The Harlem Globetrotters' chartered plane crash lands on the atoll inhabited by the happily marooned Gilligan and fellow castaways, and they all must play basketball against a specially programmed squad of robots controlled by a mad scientist.

When a decaying Russian satellite crashes on the island, the Professor uses a key component for a barometer. With that device, he learns that a massive wave is going to swamp the island. In desperation, the castaways lash their huts together into one structure in order to have any chance to ride the disaster out.

A campy look at the making of the 1964-67 TV series, as told by stars Bob Denver, Dawn Wells and Russell Johnson, as well as in flashbacks (actors play the castaways). Bob/Gilligan: Jon Wellner. Dawn/Mary Ann: Samantha Harris. Tina/Ginger: Kristen Dalton. Alan/Skipper: Eric Allan Kramer. Russell/Professor: Michael Wiseman. Jim/Mr. Howell: Steve Vinovich. Natalie/Mrs. Howell: E.J. Peaker. Sherwood Schwartz: Aaron Lustig.

The slapstick adventures of hapless Gilligan, long-suffering Skipper and their gang of mismatched castaways, all stranded on an uncharted desert isle after their tiny ship hit stormy weather.