A kindly, elderly couple who run a New York City boarding house form the steady center around which the lives and loves of their various residents unfold. Borrowed money, a lovelorn chorus girl, and a tragic misunderstanding set in motion the chain of events in East of Fifth Avenue’s tender pageant of life.

Nancy helps two aging spinsters fulfill the byzantine provisions of their father's will, but the murder of their chauffeur complicates matters.

Sam Bisbee is an inventor whose works (e.g., a keyhole finder for drunks) have brought him only poverty. His daughter is in love with the son of the town snob. Events conspire to ruin his bullet-proof tire just as success seems near. Another of his inventions prohibits him from committing suicide, so Sam decides to go on living.

A mother wishes for the return of her dead son, a wish that is granted by the severed paw of a dead monkey.

This turn-of-the-century tragedy chronicles the sorrowful travails of a woman who endures a series of devastating losses.

Ulysses Crickle owns a small town grocery store, doubling as the post office, dealing with the peculiarities of the townspeople. Jerry Fleming arrives to run a rival business and to romance Crickle's granddaughter Marian.

A mother from Arkansas is very possessive of her grown son. To prevent him from getting married she has him drafted into WW I.

Haunted by the memory of Walter Holderlin, a soldier he killed during World War I, French musician Paul Renard (Phillips Holmes) confesses to a priest (Frank Sheridan), who grants him absolution. Using the address on a letter he found on the dead man's body, Paul then travels to Germany to find his family. As anti-French sentiment continues to permeate Germany, Dr. Holderlin (Lionel Barrymore) initially refuses to welcome Paul into his home, but changes his mind when his son's fiancée Elsa identifies him as the man who has been leaving flowers on Walter's grave. Rather than reveal the real connection between them, Paul tells the Holderlin family he was a friend of their son, who attended the same musical conservatory he did. Although the hostile townspeople and local gossips disapprove, the Holderlins befriend Paul, who finds himself falling in love with Elsa (Nancy Carroll). When she shows Paul her former fiancé's bedroom, he becomes distraught and tells her the truth. She convinces him not to confess to Walter's parents, who have embraced him as their second son, and Paul agrees to forego easing his conscience and stays with his adopted family. Dr. Holderlin presents Walter's violin to Paul, who plays it while Elsa accompanies him on the piano. The film's original title, The Man I Killed, was changed to The Fifth Commandment to avoid giving "wrong impressions in the minds of the public about the character of the story." It ultimately was released as Broken Lullaby.