Jolley is the leader of the Devil's Brand gang of rustlers. When Molly Dawson sends for the Texas Rangers, Tex, Jim, and Panhandle arrive pretending not to know each other. But eventually their identities become known and they are captured by the gang.

A mad doctor (Bela Lugosi) and his helpers (John Carradine, George Zucco) lure girls to his lab for brain work, to help his wife.