Anton Schneider says goodbye to his wife Luise in tears and dies. Schneider was seriously ill with multiple sclerosis and was diagnosed by neurologist Dr. Hoffer medically treated. Luise Schneider reports the doctor and accuses him of incorrect treatment of her husband, which ultimately led to his death. The mandate against Dr. Hoffer takes over Dominique Kuster, who entrusts her employee Thomas Borchert with the investigation.

When Lisa's younger sister suddenly disappears without a trace, she returns to her home village to search for the missing girl on her own. But before she can follow up a real lead, a dead girl is found by the river.

凱勒警探即將退休，一樁陳年舊案因人類骨骸出土而重啟調查。他小女兒的同學在15年前失蹤，現在他決心破案，即便家人涉嫌也在所不惜。