Deprived of her mother's attention and love throughout her life, Seniha grows up with a deep sense of jealousy towards her older brother, Halit. For her beauty-obsessed mother, Seniha is the ugly duckling, completely unfit for her noble and wealthy family. Her older brother, Halit, is the opposite. He is her mother's pride in every sense. Halit attends the best schools and takes advantage of the family's resources. He becomes both the country's most successful lawyer and its most promiscuous bachelor. Seniha, however, sinks deeper and deeper into the depths of her sense of worthlessness. She never finished school, never married, and has practically become a servant in her own home. She has become, as her older brother calls her, "Miss Nobody.

Eylul the stubborn, school girl turns up to be a strong professional doctor by the help of her teacher Ali Asaf. After years of separation they meet up again but not as a teacher and student, instead as surgeons working side by side. Their love is met by many challenges and the inner conflict of the stubborn women who refuse to yield easily to her heart, refusing to repeat the miserable story of her dead mother.

In 1970s Istanbul, a man's forbidden love for a shop-girl evolves into a lifelong journey of obsession and longing.

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