Moving Picture World described the film: "There is a small need to describe this subject as the poem of Lord Tennyson is so well known, so suffice it to say that this Biograph subject is an unusually faithful portrayal of that beautiful romance of Enoch Arden, Annie Lee and Philip Ray, taken in scenes of rare beauty". This is the combined feature version of Enoch Arden Parts I and II.

After the Civil War, an ex-soldier and his family settle in the Dakota Territory. The son quarrels with the father and leaves home. Riding in the hills, he spots a band of Indians attacking a neighboring homestead, and he races back to warn his family as the Indians chase him.

Annie remains faithful to her husband, Enoch, even though he's been lost at sea for many years. Finally her grown children convince her to marry Philip, her former suitor. Enoch is rescued from the deserted isle where he has been stranded, and returns home. He discovers Annie's new life, and decides not to interrupt her happiness.

In China, before leaving for America, Charlie Lee promises that he will never dishonour his family by cutting his pigtail. Later, as a laundryman in a California mining town, Charlie is tormented by local men but is finally befriended by a young woman and her cowboy sweetheart. One of Charlie’s tormentors is a well-dressed idler and, secretly, a bandit who robs the mail. The cowboy and the bandit become rivals for the girl’s affections. Suspicious of the bandit, Charlie follows him, observes him robbing a mail-carrier, and contrives to capture him, cutting off his pigtail to bind the bandit. Rewarded for the bandit’s capture, but disgraced in his own eyes for dishonouring his family, Charlie gives the cash reward to the young couple and surreptitiously leaves Golden Gulch.

A rich nobleman steals a perfume merchant's wife just prior to the French Revolution, in which the perfumer is a leader of the peasants. His priest made him swear an oath to leave vengeance to God, however.

In the Kingdom of Never-Never Land there live a great Lord and Lady, each presiding over their own domain. This great Lord goes for a stroll through his estate and coming to the border of his own land he is struck by the entrancing beauty of the contiguous estate, so like his own, that the inclination to intrude is irresistible. His peregrination is halted by the appearance of the great Lady, who is indeed as fair as the flowers that clothe her land. He introduces himself and invites her to stroll with him in his gardens. She is in like manner entranced by the beauty of his possessions. How alike in beauty are they; a veritable fairyland. If they were only one, for it seems they should be. This thought is mutual, and the Lord proposes a way, a marriage, and so a betrothal of convenience ensues. They know nothing of love and so are content in the anticipation of being Lord and Lady of all Never-Never Land.

A young maiden is seduced by a charming traveling peddler who persuades her to steal from her host family in order to repay his gambling debts.

An elderly carpenter is told by a doctor that his wife is seriously ill. Soon afterwards, an insensitive shop foreman lays him off from his job because of his age. Unable to find work, and with his wife's condition getting worse, he soon becomes desperate.

A wagon train heading west across the great desert runs out of water, and is attacked by Indians. One man -- their last hope -- is sent out to find water.

Ramona, residing on her wealthy Spanish adoptive mother's rancho in California, falls in love with the Indian Alessandro. When Ramona is denied permission to marry Alessandro, the lovers elope, only to find a life of great hardship and unhappiness amidst the greed and injustice of the white landowners.

During the Civil War a young soldier loses his nerve in battle and runs away to his home to hide; his sister puts on his uniform, takes her brother's place in the battle, and is killed. Their mother, not wanting the shameful truth to become known, closes all the shutters (hence the film's title) and keeps her son's presence a secret for many years, though two boyhood chums stumble upon the truth...

Enoch Arden, a humble fisherman, marries Annie Lee. He signs on as a sailor to make more money to support their growing family. A storm wrecks his ship, but Enoch swims to a deserted island. Annie waits vainly for his return.