An American man who falls in love with a Moroccan woman realizes their romance could cost them both their lives.

The brutal hunt for the pure bloods continues as the ultimate vampire hunter, Blade, battles to defeat the House of Chthon, an ancient evil sect of vampires that is growing stronger everyday. Led by the vampire overlord Marcus, their objective is to create a vaccine that will give rise to a new breed of super vampires, immune to vampire weaknesses.