When a new strain of marijuana is delivered to a remote strip club, an army of insect creatures hungry for human blood starts feeding on the staff and patrons. Soon the bugs cause provocative havoc as their bite elicits a particularly potent narcotic reaction in those bitten.

When a small research plane carrying a group of science students and their professor crash-lands in the middle of nowhere, the survivors go to a nearby farmhouse to look for help but soon find themselves besieged by giant mutant spiders.