An outlaw murders several Apaches and flees to a stagecoach way station with the tribe in hot pursuit. A stagecoach and its passengers have just pulled into the station, as has the stationmaster's father, a former bandit named Peso, and they all find themselves besieged by the Apaches, who want them to turn over the killer to them or they'll take the station and kill everybody. The problem is that the people in the station aren't sure just who among therm is the actual killer.

The brother of a notorious outlaw is put in a charge of a stagecoach line way station in dangerous Apache territory. A stagecoach arrives at the station with a valuable box of cargo, and the outlaw brother soon shows up, though denying that he's planning to take the cargo box. Soon, however, rampaging Apaches attack the station, and the station manager, his brother and a disparate group of passengers and employees must fight them off.

Story follows a stagecoach ride through Old West Apache territory. On board are a cavalry man's pregnant wife, a prostitute with a broken heart, a Marshal taking in his prisoner Johnny Ringo, a crooked gambler, and the infamous Doc Holliday

A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.