A teenage boy befriends an escapee from a mental institution who sees visions of horrible murders being committed.

At Guesta Verde University, deranged Professor Curien is trying to revive the dead, killing students for the experiment. As such, there's an outbreak of zombies, and the government sends a NSA medical research team, formed by Dr. Alexandra 'Nightingale' Morgan and Lt. Ellis, with a special force leaded by Lt. Dalton, trying to get the zero sample from the first generation zombie. The team has little time to accomplish and depart before missiles are sent to destroy the area.

二十年前，艾德.哈里（兰斯·亨利克森）最后一次用魔法召唤恶魔复仇者南瓜头。 在一个南方小镇，居民们发现了镇上的医生（道格·布拉德利）出售他们的器官，把尸体扔到沼泽里，他们去找老巫婆哈吉丝，请她召唤魔鬼的愤怒，为他们死去的亲友报仇。于是魔鬼从艾德的遗骸里走出来，作恶人间，小镇成了一片苦海。直到二十年之后，南瓜头终于再次回来复仇了