A year after Sheila is killed in a hit-and-run, her multimillionaire husband invites a group of friends to spend a week on his yacht playing a scavenger hunt-style mystery game — but the game turns out to be all too real and all too deadly.

Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.

After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Jane's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.