Set during the reign of King Injong, the protagonist is a royal physician desperate to cure his ailing daughter. He becomes a fugitive when he gets entangled in an assassination plot to poison the crown prince, and fights to save both his daughter's life and his own.

Eun-sik tries to pass the state exam while studying in college after his military service. One day, he meets a beautiful woman Eun-hyo, and his life changes.