Charismatic Nolan Bentley wakes up in the middle of a remote forest, tied to a tree with no recollection of how he got there. With his time relentlessly running out, a mysterious stranger appears and he must finally reckon with the demons of his past and fight to survive to find a way out of his nightmare.

Medical student Ted Grey graduates at the top of his class and quickly joins an elite pathology program, whose top students invite him into their circle. There he uncovers a gruesome secret: They play a game in which one tries to commit the perfect, undetectable murder, then the others compete to determine the victim's cause of death.