民国初期，五命河接连发生悬案。河神八爷和徒弟月儿在村民秋生的邀请下，为自己中邪的姐姐驱除邪祟。随着八爷的到来，慢慢揭开了五命河死亡案件背后的真相，原来这一切和当地富绅少爷钱金明脱不了干系，而接连惨死的村民背后，也暗藏了一起人性惨案。

Three years ago, assassin Tide betrayed her organization by refusing to carry out a kill order. After escaping death, she adopted the alias Minghui and lived in seclusion in a small town with her blind sister Mingzhu, running a coffee shop. An accident exposes their whereabouts, and former accomplices track them down, catching Mingzhu in a manhunt. To save her sister, Chao Xi is forced to return to the killing game, and her hidden identity is revealed amidst the gunfire.

一个名为白云斋的棺材铺，都说只要和它有关的人，都会五弊三缺。镇子上连续发生怪事儿，先是刘麻子被井中水鬼夺命，后是杀猪匠被阴差勾了魂后，竟将全家杀害。事情诡异离奇，云游山人马三爷决定来到白云斋抓鬼驱邪。