A lonely college coed wins a paid vacation to a remote seaside resort for spring break, but when one of her fellow guests leaves and the proprietors display a curious penchant for gluttony, she begins to think something is amiss.

Earl Pilcher Jr. runs an equipment rental outfit in Arkansas, lives with his wife and kids and parents, and rarely takes off his gimme cap. His mother dies, leaving a letter explaining he's not her natural son, but the son of a Black woman who died in childbirth; plus, he has a half brother Ray, in Chicago, she wants him to visit. Earl makes the trip, initially receiving a cold welcome from Ray and Ray's son, Virgil. His birth mother's sister, Aunt T., an aged and blind matriarch, takes Earl in tow and insists that the family open up to him.

Crawldaddy and her two kids are travelling across the country on the search for victims. The dysfunctional family has the disturbing habit of skinning people alive before killing them. When their van breaks down, they are put up by a friendly couple.