An investigation into a serial killer leads two detectives to discover that Dr. Frankenstein and his creature are still alive after two centuries of genetic experiments.

Suburban America gone haywire. In the midst of a serial abductor/killer's rampage, a beautiful young teen, Riley Lawson, goes missing. When her desperate parents, Will and Kate, are contacted by her kidnapper, an insufferable FBI Special Agent takes charge of the case.But, from deep within the psychopathic subterranean world created by Otis, Riley turns the tables on her tormentor, manages to escape and to contact her parents. And, fed up with the tragi-comic inability of the FBI to find their girl, Will, Kate, and Riley's brother, Reed decide to take matters - and justice - into their own hands. But when Otis's brother, Elmo, shows up unexpectedly, the Lawsons find themselves mired in unusual and macabre consequences of vigilantism.

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Freedom from the cartel is seemingly within reach, but fraying familial bonds may prove to be the Byrdes' ultimate undoing.

Business as usual? No such thing. As Marty and Wendy clash over whether or not to expand, a surprise visitor turns their personal lives upside down.

They're back the ghouls and vampires, the ghosts and spirits and even more terrifying entities. And wherever these evil beings are, you'll find brothers Sam and Dean Winchester, hunters on the trail of the demon who murdered their mother…and of any other unholy agent of the Supernatural. Join the brothers in their mind-bending, bone-chilling Season 2 road trip across America a journey deeper into the mystery of their own destinies.