In the near future, the earth is devoid of women due to a virus that will lead to the extinction of the human race. In the meantime, a murder occurs at a research institute that was developing a vaccine. Kiriyama of the Public Security Bureau goes to the scene and finds that the murderer is his colleague Kaneshiro. He had already been infected with some kind of virus...

Hatsune, currently unemployed, lives with her lesbian friend, Mika. She had been dating a man named Kokubu, but their relationship ended in a chaotic scene when his wife showed up while they were having sex. Although devastated by the deception, Hatsune managed to bounce back thanks to Mika's support. Then, one day, her older sister Shizuka revealed that she had a new boyfriend named Itoyama. However, Itoyama turned out to be a marriage fraudster who was actually after Shizuka's savings...

Ultraman and his comrades from M-78 (including a new Ultraman, Zero, the son of Ultra Seven) join forces with other allies to fight a massive army of giant monsters led by the evil Ultraman Belial.