The baby sitter is none other than veteran Hollywood tough guy Tom Neal. A private detective, Neal is hired to keep an eye on the child of married couple George Meeker and Rebel Randall. Actually, Meeker and Randall are jewel thieves, and their "baby" is their stolen loot. Neal eventually catches on when he realizes that this is the quietest child on earth. Running a scant 41 minutes, Case of the Baby Sitter was designed to be shown in tandem with another Screen Guild Productions "briefie," The Hat Box Mystery: the films were shot back to back, with Tom Neal and Pamela Blake starring in both.

Frank James resents and tries to stop a ruthless drifter who has adopted the name of his dead brother in order to duplicate his crimes.

Susan Hart, assistant to private detective Russ Ashton, is given a camera concealed in a hat box and assigned to take a picture of a woman. A gun is accidentally hidden in the box and the woman is killed. Susan is charged with murder, but Russ and his less-than-useful associate, Harvard, get on the case.

A man escorts a wagon load of Kentucky rifles through Indian territory and must find a way to get through without losing the rifles to the Indians. Unfortunately the Indians know about it, and give the occupants an ultimatum: either the rifles or their lives.