Orphan prodigy singer runs away from her oppressive aunt and tricks a rural couple into adopting her.

San Antonio Rose is an amiably wacky mini-musical evenly divided between its "official" stars, The Merry Macs, and a strong cast of supporting clowns. Robert Paige plays roadhouse operator Con Conway, whose establishment is in danger of being squeezed out by its competition. Stranded entertainers Hope Holloway (Jane Frazee) and Gabby Trent (Eve Arden) decide to revivify Conway's establishment by staging an energetic floor show built around the talented Merry Macs. A rival club owner dispatches his two top hooligans Jigsaw Kennedy (Lon Chaney Jr.) and Benny the Bounce (Shemp Howard) to wreck Conway's club by posing as waiters, but the two stupes are easily cowed into submission--by the leading ladies!

Having paid for the education and legal training of his younger brother, Bruce, with the idea that he would become a lawyer and join his business, Frederick Garth, a racketeer posing as an honest businessman, is dismayed when he learns that Bruce has become a G-Man instead.

A temperamental singer's murder leaves a nightclub full of suspects.

J. P. Courtney wants to update the music on the radio program he sponsors, but his wife, Agatha Courtney, is the final authority and addicted to the classics and won't allow him to replace Professor Bistell and his symphonic orchestra. Conspiring with his daughter Sue and her friends, Marvo the Great, the Andrews Sisters, Anne Payne and bandleader Woody Herman, they devise a sabotage plot that gets rid of Professor Bistell, and a new sound is soon heard on the program.

Elmer Whippet inherits the Whippet Pickles company and sets out to meet the two stars, Mary Reynolds and John Stowe, of the radio program sponsored by his company, as he thinks their on-air quarreling is real. Two former associates, Jules Kinsey and J.M. Snow cross him up by substituting Susan Blair, an office secretary, for Mary and Elmer thinks the show's writer Paul Stevens is John.

A crook becomes the victim of a crafty card player who works for the District Attorney.

A former college football hero and his college sweetheart get married. Marital turmoil ensues as her criminal law practice soars while he cannot get his career as an architect off the ground. They separate, and the man begins making extra money by singing in a nightclub. When he is unjustly accused of murder, it is up to his estranged wife to defend him in court.

A stubborn farmer is raising his children alone. When his oldest daughter gets a suitor, the father nearly goes on the rampage, but he is forced to change his tune when he is injured, leaving her in charge of the farm.

In Tangier, disgraced American war correspondent Paul Kenyon, café dancer Rita and local entrepreneur Pepe join forces to battle a Nazi diamond smuggler.

After a young woman is coerced into prostitution and her brother framed for murder by an organized crime syndicate, retribution in the form of an ape visits the mobsters.