Drac has happily settled into retirement while Mavis takes the reins of the legendary monster hotel. But when a series of spooky and unexplained happenings sends chills through the resort, the Drac Pack embarks on its most spellbinding adventure yet: uncovering the mystery behind the haunting of Hotel Transylvania.

When Van Helsing's mysterious invention, the "Monsterfication Ray," goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy.