With the world gripped by a deadly pandemic, science denier Glenn Rollins turns to an experimental vaccine as treatment for a lingering sickness. Much to the surprise of his doctor, wife, and friends, the remedy immediately fixes what ails him. But Glenn will soon discover the only thing more fatal than the virus... is the cure.

Crawldaddy and her two kids are travelling across the country on the search for victims. The dysfunctional family has the disturbing habit of skinning people alive before killing them. When their van breaks down, they are put up by a friendly couple.