Mallory is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava, an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina; and an armed governmental agent named Durand.

Anna is living with "face-blindness" after surviving a serial killer's attack. As she lives with her condition, one in which facial features change each time she loses sight of them, the killer closes in.