A routine domestic flight turns into the flight from hell through a series of inexplicable phenomena and raw terror. Surreal encounters blur the boundaries between reality and nightmare. Passengers fight against all the odds in an attempt to survive while combating bizarre technological malfunctions, accelerating supernatural events and alien influences.

Gripped by a violent, terrifying illness, Rose lives in seclusion with her husband, but the arrival of a stranger shatters the fragile refuge they have built.