In a post-apocalyptic world, a family seeks refuge in Safehaven, a community protected from the ravages of the outside world by a contingency of armed guards. However, once they settle into Safehaven, they discover that the guards run the community with an iron fist, and their brutal tactics have spawned a resistance movement that tries to enlist the aid of the new arrivals.

Hilarity ensues when friends Jeff and Derek try to enter the world of back bar wrestling; where the most beautiful girls could beat the tar out of both of them without a second thought. Even with a little help from the notorious Buckle Girls, can Jeff survive a fight against Switchblade Rick for not only the title, but the heart of the girl he loves?

A rich actress who has gotten too old for leading roles employs a scientist who is working on a formula for eternal youth. The formula involves withdrawing certain fluids from the human brain. She takes the serum, but its unforeseen side effects turn her into a murderous monster.