In a post-apocalyptic world, a family seeks refuge in Safehaven, a community protected from the ravages of the outside world by a contingency of armed guards. However, once they settle into Safehaven, they discover that the guards run the community with an iron fist, and their brutal tactics have spawned a resistance movement that tries to enlist the aid of the new arrivals.

A rich actress who has gotten too old for leading roles employs a scientist who is working on a formula for eternal youth. The formula involves withdrawing certain fluids from the human brain. She takes the serum, but its unforeseen side effects turn her into a murderous monster.