Hernandez, the sheriff of a small Mexican village, joins a group of townsmen with the intention of killing young orphan Manuel and robbing him of his inheritance. Killer Luke, now an alcoholic for having murdered his own son by mistake, who is chosen for the task, instead decides to take the defence of the poor child.

Maciste travels to Egypt, where he leads a revolt against an evil queen. In Son of Samson, Maciste (Mark Forrest) -- scion of the famed muscleman -- travels to the Egyptian city of Tanis to checkmate villainous Queen Smedes (Chelo Alonso), who's persecuting the citizenry.