Queen of Housewives depicts the life of "naejo," housewives who devote their entire lives to their husbands' success, but with a more comedic and aggressive twist.

When a popular anchorwoman for a prime time news show becomes the suspect in a murder case, her estranged husband - who has worked as a prosecutor in the past but now works as a public defender - decides to defend his wife.

After Gyeong-bae's son is kidnapped, he receives a call from the kidnapper asking for 100 million won. The detectives are teamed up for the case, yet the culprit gets away at every opportunity.