Journalist Mike Harway decides to help his friend Christine in her search for her father, professor Baker, who mysteriously disappeared. The investigation brings them to Africa where they are captured and brought to the El Faium abandoned fort. It now hosts a laboratory designed by the twisted mind of Devilman, who dreams of swapping his natural brain with an artificial one that will make him perfect.

Yaguine and Fodé, two teenagers from African Guinea, wrote a letter to the "European Parlament great leaders", on behalf of all children and teens in Africa, where they ask for help with food, health and education. Ten years later, thirteen-year-old Thabo embarks on an epic journey with his friend Rocco from Bari to return to his own African village of 'Ndula to escape a ruthless Italian gang who are exploiting young football players.