The two central characters are breaking up. Moira flees to Paris; Stan goes up north with gay writer friend, Timothy. Moira returns and joins Stan and Timothy up north to sort things out. Roberta, Stan's old friend also arrives. The next 24 hours reveal the assortment of tensions, expectations, humour and discontents of four people experiencing the difficult transition to middle age. The four characters return to Toronto to resume their separate lives.

Skin is not a documentary, but an evocative and moving dramatization of women coming to terms with the pandemic that is AIDS. The metaphoric voice of the skin provides a counterpoint as four women talk about how AIDS has disrupted their lives. Brenda and Hedde courageously address the isolation and stigma of their personal lives when they go public as People Living With AIDS (PLWAs). Ann and Lucille confront (through each other), the complex social, cultural and medical agendas surrounding women and AIDS. In Skin, women speak powerfully and urgently of their experience with AIDS, their voices breaking through the silence of neglect created by the media.