With the world gripped by a deadly pandemic, science denier Glenn Rollins turns to an experimental vaccine as treatment for a lingering sickness. Much to the surprise of his doctor, wife, and friends, the remedy immediately fixes what ails him. But Glenn will soon discover the only thing more fatal than the virus... is the cure.

Brimstone Incorporated features three ghoulish tales of terror and a wraparound, the latter centering around a law firm that serves as the gateway to Hell. Stories include Mama's Boy, First Date and Skunk Weed,

Randy is an awkward groundskeeper who is obsessed with professional wrestling. Longing for a sense of belonging with grandiose dreams of becoming a wrestling superstar, Randy is only met with abject humiliation and alienation. A brutal shaming at a local wrestling school pushes Randy over the edge and lights the spark for his blood lust. Donned in wrestling gear and armed with homicidal rage, Randy sets out on a blood soaked rampage to punish those who wronged him. With each ghastly kill, Randy takes a trophy from his tormentors to add to a wrestling title belt crafted from human flesh. The only hope of putting an end to his reign of carnage lies with Becky, an understanding client who is one of the only few to ever show him kindness.

Gary is a trailer park romance novelist who can't seem to sleep at night. He also thinks that he saw a monster assaulting his girlfriend while she was sleeping. People is his trailer park begin to die in their sleep. Soon, Gary's friends begin to think that he has gone crazy with all his ranting and raving and that all he needs is a good night's sleep. Gary is afraid to sleep...

Terror and death plague a gloomy, coastal metropolis, as a vampiric entity known as 'Pharisee' feeds on the blood of the city's populous. As the police struggle to find the blood-thirsty maniac, a deranged escort named Zoe is unwillingly brought into his world in this bloody rock and roll fueled nightmare.

On the depraved streets of Cleveland, young women are dealt hard lives. Trudging through days of filth, poverty and crime, they do what they can to survive.

While shooting a documentary on the suspicious disappearances within the homeless community, a filmmaker and his crew go missing while uncovering a terrifying and vicious secret below the city's surface.

Crawldaddy and her two kids are travelling across the country on the search for victims. The dysfunctional family has the disturbing habit of skinning people alive before killing them. When their van breaks down, they are put up by a friendly couple.

While on a stakeout, hardboiled cop Eddie Boone gets injected with a dangerous new designer drug causing nightmarish side effects. As he searches for his missing partner, Eddie discovers the urban streets full of mutants, monsters, and mayhem orchestrated by the mastermind behind the lethal narcotic.