Prizefighter Mason loses his opening fight so wife Rose leaves him for Hollywood. Without her around Mason trains and starts winning. Rose comes back and wants Mason to dump his manager Regan and replace him with her secret lover Lewis.

In 1987, Robert Crumb presents himself: raised by a Marine father, educated in Catholic schools, married at 21 in Cleveland where he worked for a greeting card company, dropping acid in 1965, heading to San Francisco and getting in on the formation of Zap Comix, gaining celebrity, loving old time jazz, starting a band, living in a commune, meeting Aline Kominsky who became his second wife and his partner in art, having a daughter, and developing a more realistic drawing style. The confessions include his loneliness, his obsessions with women, his bewilderment by fame, his sense of the disintegration of Sixties' subculture, his nervous breakdown in 1973, and his peace now.