Pick-up artist Jerry Sloane is hired by mobster Ernie Pulaski to lure girls for his white slavery ring. Once Ernie gets his claws on them, the victims are turned over to mute Mama Lupo (she lost her tongue after tattling on some fellow schoolgirls), who tortures them in her dungeon and addicts them to heroin. Jerry unwisely falls for Ernie's daughter, resulting in a particularly painful, if appropriate, vengeance.

In a small college town, a recent spate of grisly slayings dubbed the "sorority house murders" has led to rumors of a so-called "blood cult" at large, composed of a number of prominent local citizens. Despite the main perpetrator having apparently jumped to their death, the gruesome murders continue unabated, with each victim bearing the signature of the cult — a golden amulet depicting a dog's head left at the scene. Returning to his hometown following the murder of his brother, Michael begins to suspect that the blood cult may have had something to do with his sibling's grim demise. Finding the authorities ineffectual, Michael teams up with his elderly childhood neighbor Gracie Moore — whose husband has recently fallen prey to the cult — and together the pair hatch a plan to put an end to the gruesome goings-on.