In this action-packed serial, government agent Quentin Locke infiltrates a corrupt patents company, only to run into the gleaming terror of its robot protector, the Automaton. In order to save the beautiful Eva Brent and find a cure for the dreaded Madagascar Madness, Locke suffers an inhuman array of tortures and physical restraints. He is chained, tied with barbed wire, padlocked in a crate and thrown in the water, tied beneath a descending elevator, strapped to an electric chair, and bound in an elaborate Oriental torture chamber.

Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.