Tico and Friends tells the story of 11-year-old Nanami Simpson and her life-long friendship with a female orca named Tico. The two have an unbreakable bond and swim with each other every day. As a result of this, Nanami has learned how to hold her breath longer and swim deeper than other humans can.

Nobita, Doraemon, and the rest must come to the aid of mermaid princess Sophia, whose undersea kingdom is suffering under the weight of a war. Their only hope lies in a mythical sword from the planet Aqua...