The adopted daughter of New-York-City gambler, Al Draper, elopes from quarantine (key plot word) with another voyager from Europe. Later she is found murdered in a hotel room. Draper is dissatisfied with the handling of the case by the district attorney and sets out to work the case himself.

Baseball star Elmer Kane leaves the little town of Gentryville, Indiana, to join the Chicago Cubs, where his naivete and arrogance soon put his relationship and career into jeopardy.