Phyllis Coates, TV's erstwhile Lois Lane, essays one of her largest film roles in Blood Arrow. Coates is cast as a devout Mormon girl whose mission is to transport smallpox vaccine to her friends and neighbors. Unfortunately, this requires her to journey through hostile Indian territory. Appointing themselves as the girl's unofficial protectors are Indian scout Scott Brady, trapper Don Haggerty and (reluctantly) gambler Paul Richards.

When a cold medicine causes Sach to be able to smell diamonds, he and the rest of the Bowery Boys are induced by a diamond dealer to accompany him to Darkest Africa in search of a legendary cache of them.

During WWII, when an allied bomber is shot down over Germany, the five surviving crew are captured but cleverly escape detention after learning German secret information and knocking out a Nazi major. With the angry major in hot pursuit, aided by military personnel, Gestapo agents and Hitler-loyal citizens, the five wend their way across perilous Germany, intent on reaching the UK with the secrets they have learned.

A woman leads an expedition into a remote jungle to find her long-lost brother, but instead finds a mad scientist who has created a fungus monster that feeds on the local inhabitants.