Following the death of a hotelier in Punta del Este, Uruguay, an unexpected inheritance dispute begins. Stallone, an actor with Down syndrome, believes he is the rightful heir to the hotel. On the other side is Magrelo, a young autistic man who was raised as an adopted son by the deceased. Without waiting for the reading of the will, Stallone decides to reunite his old friends with Down syndrome from the institute where they lived in Brazil to spend a week's vacation at the hotel.

500 years into the future, the earth is a dry wasteland destroyed by humans. Doctor Alma, a fluffy, brilliant Vulkeet (a cross between a parakeet and vulture) who drives a Vespa, must cure the only creatures left who can save the world by bringing back the rain - the bizarre and loveable Homeys who have fallen ill with a mysterious sickness.