A year has passed since a series of gruesome murders took the lives of multiple college seniors aboard the now infamous Terror Train. The survivors are coerced to go on a New Year's Eve redemption ride aboard the very same train, where a new kind of evil awaits and the terrified passengers must once again fight to survive the ride.

It follows a college student as she boards a party train for Halloween, and ends up fighting for her life when a mysterious assailant begins killing the people one-by-one.