The boys are a dentist and his assistant traveling to the Old West to open a new practice. Once in town, they buy a business--only to wake up the next day and see that the entire population of this bustling town had left for the California gold fields early that morning! Then, they discover an evil plot to sell out these settlers to some hostile Indians, so they spring to the rescue.

Notorious racketeer Joe Albany kills James Flowers when he discovers he is embezzling from the club they own. Joe escapes through a window and hails a taxi, but when he gets nervous at the sound of sirens, he jumps out. Hardware salesman Peter Harris accidentally hits Joe with his car, and unharmed, Joe seizes this opportunity to hide in Peter's car. Peter is so drunk that Joe is able to con him into believing that he is Charles Edwards, a fellow hardware man who was with him at a convention, and in the guise of friendship, accompanies Peter to his suburban home. The next morning, Joe gets antsy and wants to leave, but Peter's family, his wife Mary, young son Robert and daughter Jane all entreat him to stay.

Awkward Annie loves her sharpshooting rival in Buffalo Bill's Wild West Show.

Mickey Lofton, young half-brother of famed war-aviator Jerry, fails in his attempt to enter the Canadian Air Corps, because of his fear of thunderstorms developed by an incident in his boyhood days. Jerry, now a Captain in the U.S. Department of Justice, is given an assignment to capture some border oil smugglers. Through his friendship with Raoul McGuire, one of the suspects, Jerry is accepted as a member of the gang. Mickey is in love with Raoul's sister, Molly. Gang leader Moran shoots and wounds Raoul, and is himself shot down by Jerry. Mickey flies Molly and her wounded brother to a hospital. Jerry takes off in another plane to guard Mickey's craft from a pursuing airplane, and crashes his plane into the gangster's plane but parachutes to safety.

Mary, a poor farm girl, meets Tim just as word comes that war has been declared. Tim enlists in the army and goes to the battlefields of Europe, where he is wounded and loses the use of his legs. Home again, Tim is visited by Mary, and they are powerfully attracted to each other; but his physical handicap prevents him from declaring his love for her. Deeper complications set in when Martin, Tim's former sergeant and a bully, takes a shine to Mary.

Heidi is orphaned and her uncaring maternal Aunt Dete takes her to the mountains to live with her reclusive, grumpy paternal grandfather, Adolph Kramer. Heidi brings her grandfather back into mountain society through her sweet ways and sheer love. When Dete later returns and steals Heidi away to become the companion of a rich man's wheelchair-bound daughter, the grandfather is heartsick to discover his little girl missing and immediately sets out to get her back.