An eccentric woman meets an equally odd man at a group therapy session and they begin a relationship.

A prostitute is murdered on the streets of a tough, low-income neighborhood. A diabetic retired boxer who knew her is appalled by the lack of interest shown in the case by the police or anybody else in the neighborhood, and decides to investigate the case himself.

Dominick DiNapoli is a man who loves food and is overweight as a result. After an obese cousin dies due to health problems, Dominick's sister Antoinette sets out to help him lose weight. Although he has a hard time trying to slim down, Dominick finds inspiration when he meets and falls for shop owner Lydia. Can he get up the courage to ask her out, or will he go back to the comfort of overeating?

Two brothers who hate themselves are going to spend Christmas with their mother. She tries to get them together.

Aspiring filmmakers Mel Funn, Marty Eggs and Dom Bell go to a financially troubled studio with an idea for a silent movie. In an effort to make the movie more marketable, they attempt to recruit a number of big name stars to appear, while the studio's creditors attempt to thwart them.

Lucky Luke becomes the Sheriff of Daisy Town and runs out all the criminals. Then the Dalton brothers arrive and try to get the Indians to break the peace treaty and attack the town.