During a medical test to join the high school soccer team, a virgin teenager is shocked to discover she is pregnant.

A 10 year old gifted boy wants to be a jazz pianist much to the chagrin of his more classical oriented piano instructor. With his mother's help, he is an underage regular at a local nightspot, where he is teamed up with a sax superstar. Both come to learn that each suffers from Tourette's Syndrome (thus the film title). The older man has developed mannerisms to cover up his own fallibilities and resents the boy and his mother's acceptance of the disease.

Fascinated by the history of his people, Alloune, an old guide at the African museum "La Maison des Esclaves" in Gorée, sets off on a pilgrimage to find the descendants of his ancestors in the United States. This moving journey takes him from the coast of South Carolina to the Harlem neighborhood of Little Senegal, home to the African community. Driven by the idea of reuniting his family across centuries and borders, Alloune traces his roots to a distant cousin, Ida, who knows nothing of his past. The old man also crosses paths with his nephew Hassan, a clandestine cab driver, his fiancée Biram, Eileen, pregnant and a runaway, and Karim, who is seeking a sham marriage to obtain a green card. All four misunderstand Alloune's quest.

Remo Street is a young fighter who comes from a world where nothing is easy, so when he is faced with the opportunity to train with a world class coach, he has to choose between the long hard road to honor and glory, or succumbing to a brutal future as a cage fighter for the Russian Mafia.